This drug may rarely cause serious liver disease. When the benefits outweigh the potential risk to the fetus. Celecoxib is used to decrease growths found in the intestines of persons with a family history of this condition. Before using this medication, tell your doctor or pharmacist if you are allergic to it or to sulfa drugs. Celecoxib is a non-steroidal anti-inflammatory drug used in the treatment of osteoarthritis, rheumatoid arthritis, and ankylosing spondylitis.