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Taking Nexium or breastfeeding your baby. Esomeprazole reduce the production of acid in the stomach, Nexium reduces the amount of acid backing up into the esophagus and causing reflux symptoms. Nexium is usually taken once a day at least one hour before meals, swallowed whole and shouldn't be crushed or chewed. If Nexium gives you an allergic reaction, you will not be able to use this medication.