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Before taking Celecoxib, tell your doctor or pharmacist your medical history, especially of blood flow problem in the brain. Celebrex works by blocking the action of a substance in the body by inhibiting the breakdown of Celecoxib in the liver. Celecoxib does not prevent the progression of either type of arthritis. Celecoxib does not prevent the progression of either type of arthritis. If you are allergic to it or to sulfa drugs. If you are already taking Celebrex, it is important to keep taking it as instructed by your doctor. The shortest time based on your treatment goals.